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• name: description content: Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.
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• property: og:title content: Baishideng Publishing Group
• property: og:description content: Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.

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• "The submission and peer review process was straightforward and professionally managed, with no notable concerns or difficulties encountered at any stage. Reviewers provided constructive feedback within a reasonable timeframe, and the editorial team remained communicative and responsive throughout. The publisher handled all correspondence promptly and courteously, and the manuscript ultimately moved through production and was published in a timely and efficient manner. "
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• "The process was quick and easy to follow. No delays were faced on the side of editors. All the requirenments were well cummicated before submitting the manuscript and even during the peer review state. editting was swift and free from any error, with great attention to details. overall a wonderful experinec with the Journal and the editting team "
• "The overall processing of the article, right from submission to the review process to proofreading to final publication, is more than satisfactory. The editorial team is very cooperative and supportive at each and every step of processing. We are very much pleased and satisfied with the services which have been meticulously offered by the editorial team. "
• "The journal and editorial board have done a great job in supporting the publication of the article. We are looking forward to publishing with F6 Publishing Baishideng group in the future. The review process is also on time and not much delay of time. The reply on the email was also very quick and helpful. The processing of the article is also quick. It is such a pleasure to publish with World Journal of Cardiology. We are looking forward to publish more manuscript ahead. "
• "投稿時の対応およびコメントに満足しております。本論文が世に公開できたことを感謝申し上げます。多くの人々に読まれることを期待したいと考えます。 この投稿を励みに今後も活動していきたいと考えます。 次回の投稿もあなたの雑誌を検討したいと考えます。 "
• "This single-centre, observational study offers pragmatic evidence to support de-escalating surveillance in presumed “innocent” BD-IPMN. The front-loaded nature of actionable findings and surgery—88% within two years—along with the predictive thresholds (serum CA19-9 ≥43 KU/L and cyst size ≥30 mm) are clinically useful and align with evolving guideline debates. Importantly, the authors highlight declining operability with time, an underappreciated real-world constraint that strengthens the case for time-bound surveillance and potential discharge at five years when cysts remain "
• "We appreciate the efforts of the editorial and production teams. The publication process was well organized and efficient. The journal demonstrated a structured and transparent editorial process. Communication was timely and professional throughout the submission and publication stages. The peer-review process was constructive and provided valuable feedback that improved the scientific quality and clarity of the manuscript. "
• "The study by Qin et al. pioneered the elucidation of the multi-target mechanism of Anwei Formula in chronic atrophic gastritis. By directly suppressing NLRP3 inflammasome activity in gastric tissue and reshaping the gut microbiota–metabolism axis, it systematically demonstrated, for the first time, the molecular basis through which traditional Chinese medicine exerts therapeutic effects via the "gut–stomach axis," providing robust scientific support for the application of multi-omics integration in modern mechanistic analysis of traditional Chinese medicine. "
• "Throughout the entire manuscript handling process, I was deeply impressed by the exceptional professionalism and authority of your journal. The peer reviewers provided highly precise, insightful, and constructive comments that reflected profound academic expertise and a rigorous scholarly approach. The editorial team was exceptionally friendly, meticulous, and professional, and their work efficiency was truly outstanding. Every interaction was handled with care and promptness, making the whole publication experience smooth and pleasant. It is a great honor to have our work published in such a prestigious journal, and I would highly recommend it to my colleagues. "
• "The Publishing Group demonstrates exceptional efficiency and quality in journal production, consistently minimizing the time from submission to online publication. Their rigorous peer review process relies on highly specialized and responsive reviewers, ensuring fair, constructive, and timely feedback. Moreover, the publisher actively promotes scholarly work through global indexing and open-access options, enabling rapid, worldwide dissemination of research. "
• "We are satisfied overall with the submission, peer review, editing, and publication process. The peer review was constructive and helped us strengthen the scientific clarity and presentation of the manuscript. We especially appreciate the professionalism and responsiveness of the editorial and production teams throughout the process. Thank you to the reviewers, editors, and publishing staff for their time and support. "
• "What impressed me most throughout the submission and publication process was the editorial office's sense of responsibility and attention to detail. Every email inquiry received a prompt and patient response. After submission, the editors carefully checked the manuscript page by page—pointing out even minor issues in reference punctuation and figure numbering. Such rigor exceeded my expectations. The reviewers' comments were professional and insightful; although they were not always easy to address, each suggestion truly targeted the core weaknesses of the paper, and the revisions significantly improved the final quality. The entire workflow was efficient, with timely updates via both the system status and email notifications at every stage, which provided me with great peace of mind. In summary, the editorial team worked efficiently and responsibly, making this a very smooth and positive publishing experience. "
• "The world journal of paediatrics is one of the Journals I respect and always like to publish in especially that I get invitation for free publications which I respect greatly. The world journal of paediatrics is one of the Journals I respect and always like to publish in especially that I get invitation for free publications which I respect greatly. The world journal of paediatrics is one of the Journals I respect and always like to publish in especially that I get invitation for free publications which I respect greatly. The world journal of paediatrics is one of the Journals I respect and always like to publish in especially that I get invitation for free publications which I respect greatly. "
• "It is deeply gratifying to see our multicenter retrospective cohort study on hepatocellular carcinoma (HCC) in Nigeria published in the World Journal of Gastrointestinal Oncology. This work represents a collaborative effort spanning multiple tertiary centers across the country, and the publication journey was one of rigorous intellectual refinement. The peer-review process at WJGO was thorough and constructive. The reviewers engaged critically with our methodology—challenging us to strengthen the statistical analysis, clarify our inclusion criteria across heterogeneous hospital records, and expand the discussion on how our findings compare with emerging HCC patterns in sub-Saharan Africa. Each round of revision sharpened the manuscript, ensuring the data we present on HCC prevalence, risk factors, and treatment outcomes is both robust and clinically meaningful. From submission to final acceptance, the editorial team maintained clear communication and reasonable turnaround times, which is especially appreciated when coordinating responses across multiple authors with demanding clinical schedules. The single-blind review process allowed honest, detailed feedback that improved the manuscript considerably. We hope this work contributes meaningfully to the evidence base on HCC in Nigeria—a disease that remains under-characterized in our region despite its heavy burden—and encourages further multicenter collaborative research across West Africa. "
• "We are grateful to World Journal of Gastroenterology for the rigorous and efficient peer review process that improved our clinical study on the resection of esophageal submucosal tumors. The editorial team’s constructive feedback helped us strengthen the clarity of our methodology and the interpretation of our findings. We also appreciate the journal’s prompt production schedule, which allowed our work to reach the gastroenterology community in a timely manner. It has been a positive experience publishing in WJG, and we hope our study contributes meaningfully to the clinical management of gastrointestinal diseases. "
• "I appreciate the time and effort of the reviewers and editors dedicated to providing their valuable comments and suggestions which helped to improve our manuscript to its high quality level. I appreciate the efforts spent for the meticulous and repeated revisions provided by the editorial and publisher members to our manuscript till its final version. I heartily appreciate the support and generosity of the company editor for facilitating publishing our articles in their respectful world's Journal series. "
• "We would like to express our sincere appreciation to the editorial team and reviewers of the World Journal of Clinical Pediatrics for their valuable efforts and professional handling of the manuscript throughout the publication process. The constructive comments, prompt communication, and high editorial standards greatly contributed to improving the quality and clarity of our work. We are truly grateful for the time and dedication invested by the editors and reviewers, and we highly appreciate the opportunity to publish our research in this respected journal. Corresponding author: Prof.Dr. Mohammed H Hassan, MD Medical Biochemistry and Molecular Biology "
• "Process worked well. Happy with the published article. This was a paper that had been previously presented at the podium for the British Association of Pediatric Surgeons. The article outlay is excellent. The editor and reviewers were persistent in demanding the very best article with nothing left to chance. We were able to respond in a constructive manner to facilitate delivery of an excellent product. "
• "I am truly grateful for the opportunity to contribute to this publication. It is incredibly rewarding to see our work recognized in such a respected journal. I deeply appreciate the mentorship, collaboration, and effort from everyone involved, and I hope these findings contribute meaningfully to the field and future patient care. "
• "I recommande WJCO for publication the article process is very meticulously driven and the quality of articles is very good reviewer comments are very helpful to us and the editor do a very good work to make sure that the article is correct and well written the figures are also well organised and accurately presented "
• "Simpler technique but critical evaluations noted. Important for patient care. Type 2 diabetes mellitus (T2DM) and diabetic retinopathy (DR) are growing global health concerns, with DR remaining a major cause of vision loss. The study identifies indirect bilirubin (IBIL) as a potential biomarker that is inversely linked to DR risk in patients with T2DM. Although the findings are clinically important, limitations such as the cross-sectional design, single-center setting, and possible confounding factors reduce generalizability."
• "This case-control study recruited 303 participants from Kunming, exploring associations between serum vitamin D, VDR FokI polymorphism and diabetic retinopathy (DR) in T2DM patients. It found vitamin D deficiency and VDR FokI ff genotype were independent risk factors for DR. The study adopted rigorous grouping and standard laboratory detection, applied Sanger sequencing for accurate genotyping, and controlled common clinical confounding factors, offering valuable population evidence for DR early risk prediction. However, single-center cross-sectional design cannot confirm causality. It lacked DR severity stratification and ignored lifestyle and sunlight exposure confounders. Future work should adopt multicenter prospective cohorts and further explore the molecular mechanism of VDR variants affecting DR pathogenesis. "
• "Formerly ,the neutrophil/lymphocyte ( N/R) ratio also reflected the severity of COVID-19. In this study, the authors state that the N/L ratio is an indicator that correlates with the prognosis of HCC receiving program inhibitor administration. NLR values have also been shown to predict survival in various cancers including urologic cancer , nasopharyngeal cancer , colon cancer , as well as lung cancer . In addition, other authors say that the NLR has been found to be a prognostic risk factor for HCC after treatments other than TACE, such as hepatectomy , liver transplantation and sorafenib therapy . Please explain the mechanism by which the N/L ratio serves as an indicator of prognosis. Explain the mechanism by which the NLR cutoff was set to 3.165. Systemic inflammatory responses have been shown to reflect the promotion of angiogenesis, and DNA damage and tumor invasion through upregulation of cytokines. A simple index of systemic inflammation is the neutrophil–lymphocyte ratio (NLR). Elevated NLR has recently been shown associated with poorer prognosis in patients with various types of malignant tumors, including colorectal cancer, HCC, intrahepatic cholangiocellular carcinoma, and pancreatic cancer. Furthermore, elevated NLR have shown a significant correlation with poor outcome in patients undergoing LT for HCC. I think that One mechanism by which elevated NLR can lead to a higher tumor recurrence rate involves an increased number of circulating neutrophils secreting the vascular endothelial growth factor (VEGF), resulting in higher levels of VEGF in the tumors. Moreover,an elevated Platelet-to-Lymphocyte Ratio (PLR), often with a cut-off , is a significant, low-cost prognostic biomarker for poor overall survival (OS) and disease-free survival (DFS) in hepatocellular carcinoma (HCC) patients. It reflects heightened systemic inflammation and correlates with tumor aggressiveness, such as large tumor size, vascular invasion, and recurrence. Please comment about platelet /lymphocyte ratio about the prognosis HCC receiving receiving program inhibitor administration. "
• "This is a well-written and presented rare case report on "Giant serosal cavernous hemangioma of the ileum". This manuscript gives additional new knowledge to the existing literature.The authors emphasize the importance of a better understanding of "cavernous hemangioma" by clinicians, and the necessity of timely diagnosis and treatment. I think that this manuscript is suitable ,and worth to be published in World Journal o Gastrointestinal Surgery."
• "This article addresses a clinically important issue in complex hepatocellular carcinoma surgery: the potential navigation value of combining intraoperative ultrasound with indocyanine green fluorescence imaging. The study is valuable because it evaluates not only tumor visualization but also clinically relevant endpoints, including tumor localization, occult lesion detection, margin control, perioperative outcomes, and survival-related outcomes. The topic is timely and relevant to hepatobiliary surgeons, particularly in the context of precision hepatectomy and minimally invasive liver surgery. However, the interpretation should remain cautious because the study is retrospective and single-center in design. Potential selection bias, learning-curve effects, and heterogeneity in fluorescence protocols may influence the results. The comparison also appears to reflect a systematic combined-navigation strategy versus conventional surgery rather than a pure navigation versus non-navigation comparison. Therefore, the findings are clinically encouraging and suitable for hypothesis generation, but prospective multicenter validation with standardized navigation endpoints is needed. "
• " The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
• " The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
• " The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
• "This study addresses an important and timely clinical question, providing relevant data on the use of ustekinumab in postoperative recurrence of Crohn’s disease. The multicenter design enhances the external validity and applicability of the findings in real-world practice. The integrated assessment combining endoscopic, clinical, and biological outcomes represents a major strength of the study. Overall, the results support the efficacy and safety of ustekinumab, particularly in a first-line setting. However, the retrospective design introduces inherent limitations, including potential selection bias and residual confounding. The relatively short follow-up period limits the ability to draw conclusions regarding long-term efficacy and durability of response. The observed differences in response among stricturing and penetrating phenotypes are intriguing but remain hypothesis-generating and require further validation in larger prospective cohorts. Despite these limitations, the study provides valuable real-world evidence supporting early use of ustekinumab in postoperative Crohn’s disease. The manuscript is well structured, clearly written, and easy to follow, with a coherent presentation of results and clinically meaningful interpretation."
• "1 Ethics: Does the ethical approval form provided by the author meet the requirements? The Ethics Committee of the Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, waived the need for ethics approval. 2 Methods: Is the experimental method effective? Can it be repeated by fellow researchers (according to adequate textual/citation content presented)? The study is moderately effective as it is retrospective clinical design how ever detailed methodology is missing. furthermore, it is judged on statistical variation not on experimental results variations 3 Results: Are the results true and authentic? Is the theory or hypothesis of universal significance validated or partially validated? The results are appropriately authentic and consistent. Sample size is lower, hence hypothesis is moderately validated. Present study demonstrate the prognosis relevance which is insufficient for application in clinical settings. 4 Figures and tables: Does the author provide perfect tables, line charts and/or graphs? Or, does the author provide figures and tables that are confusing, poorly constructed and/or not well-annotated? Figure and tables are adequately presented 5 Biostatistics: Does the author provide perfect biostatistics data? Or, does the author provide tables and line charts that have mistakes in the data? Standard statistical approach is used in the current study with respect to study design 6 References: Does the author scientifically and reasonably cite the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study? Or, does the author self-cite, omit, mis-cite and/or over-cite references? Appropriate 7 Language: Does the language in article correctly, clearly and concisely express the information? Or, does the article have multiple grammatical and spelling mistakes? Acceptable format, formal and scientifically clear 8 Caveats or drawbacks: What are the caveats or drawbacks for the results? Single center results Lower sample size which might effect on statistical significance Transparency in methodology "
• "This review article explores the complex relationship between nutrition, ultra‑processed food consumption, and colorectal cancer development. It highlights how diets rich in additives, refined sugars, and industrial fats contribute to dysbiosis, inflammation, and oxidative stress, thereby increasing cancer risk. Conversely, dietary interventions such as fasting, caloric restriction, and ketogenic regimens show promise in reprogramming tumor metabolism and enhancing therapeutic responses. The authors emphasize that while mechanistic evidence is strong, clinical studies remain limited, heterogeneous, and often small in scale. Overall, the paper underscores the potential of personalized nutrition as a complementary strategy in colorectal cancer prevention and treatment, but stresses the need for well‑designed trials to validate safety, adherence, and long‑term outcomes."
• "This article provides valuable insight into the role of CD161⁺CD8⁺ T cells in HBV‑associated hepatocellular carcinoma, emphasizing their contribution to T‑cell exhaustion. The study highlights that PD‑1 inhibitors reduce PD‑1⁺ subsets but fail to affect CD161 expression, suggesting independent regulatory mechanisms. These findings underscore CD161 as a distinct and promising immunotherapeutic target, complementing but not overlapping with PD‑1 blockade strategies. While the evidence is compelling, broader patient cohorts and longitudinal studies will be essential to confirm clinical relevance and therapeutic potential."
• "The study presents a novel synthetic lethality strategy combining atorvastatin and gefitinib for colorectal cancer. It demonstrates strong experimental evidence with both in vitro and in vivo validation, highlighting mechanistic clarity via the AMPK‑SREBP1 pathway. While promising and translational, limitations in sample size and treatment duration suggest further clinical validation is needed."
• "The work is very interesting. In particular, the discussion is rich and leads to many insights into the relationship between diabetes and coronary heart disease (CAD) and how to address both simultaneously in a prevention strategy. This paper could be a trailblazer for further research investigating the use of other drugs currently used to treat both diabetes and CAD."
• "The authors deserve praise for coming up with a new and well-thought-out way to solve a difficult clinical problem. This case report beautifully shows how customised three-dimensional printed titanium ribs can be used successfully with bilateral flap coverage to fix a complicated chest wall defect. Combining cutting-edge 3D printing technology with sound reconstructive surgical principles is a forward-thinking approach that works well and looks good. The manuscript is well-organised, clearly written, and backed up by relevant clinical information and images. It gives thoracic and reconstructive surgeons a lot of useful information about planning before surgery, customising implants, and surgical techniques. This report adds important information to the growing field of personalised surgical reconstruction and sets a good example for how it can be used in the future."
• "The manuscript "Management and Prevention of Iatrogenic Ipsilateral Femoral Neck Fracture During Intramedullary Nailing of Femoral Shaft" talks about a clinically important but often overlooked problem in orthopaedic trauma surgery. The authors did a great job of stressing how important it is to be careful during intramedullary nailing. They also talked about both ways to avoid problems and how to handle them when they do happen. The article is well-organised, with a clear progression from identifying the problem to finding solutions that work. The focus on early diagnosis, safety measures during surgery, and imaging protocols adds a lot of clinical value. The section on technical details and surgical tips is especially interesting, making the paper very useful for both new and experienced surgeons. The manuscript adds to the existing body of literature by putting together current evidence and making recommendations that can help lower complication rates and improve patient outcomes. In general, this article is well-written, informative, and useful in a clinical setting, so it should be published."
• "Congratulations on the publication of your paper. This is a significant achievement, and I am delighted to see that your dedicated efforts in daily clinical practice and academic work have borne fruit. I read your paper with great interest, particularly because my own specialty is emergency medicine. I also occasionally encounter cases of anorectal foreign bodies in clinical practice, and I believe your paper will serve as a highly valuable reference for the management of such cases in the future. The manuscript is very well organized, clear, and easy to follow. In addition, it incorporates up-to-date information and presents the topic in a balanced and informative manner. Overall, I consider this to be a high-quality paper of substantial clinical value. In recognition of these strengths, I would give this work the highest evaluation. Writing and publishing a paper while maintaining a busy clinical workload is no small accomplishment, and I sincerely hope that you will continue to build on this success and further expand your academic achievements. Congratulations once again on this excellent work."
• "5-FU is the basis of the therapeutic regimens for the pharmacological treatment of gastric cancer (GC). However, the main downside of this treatment is the development of resistance, which, understandably, negatively affects patients’ clinical outcomes. Therefore, innovative therapeutic strategies are needed to overcome 5-FU resistance and improve the prognosis of GC. The authors of the study under review investigated the effects of Xiangshaliujunzi decoction (XSLJZD) on GC cell lines. They found that XSLJZD inhibited cell viability and proliferation, while promoting PANoptosis in 5-FU-resistant cells. Suppression of ZEB1 increased pyroptosis, apoptosis, and the expression of other proteins associated with programmed cell death. The selection of this work for comment was based on two reasons: i) the use of complementary therapy, whether or not based on traditional Chinese Medicine in the treatment of various benign and malignant digestive disorders, should be adopted internationally. The results are no longer empirical but are based on valid clinical and laboratory data, ii) The authors, in designing their study, among other things, investigated the effect of PANoptosis processes (apoptosis, pyroptosis, and necroptosis) which are a very hot topic of research internationally not only in malignant digestive diseases, but also in a host of other benign conditions such as inflammatory bowel disease. Their results, although experimental, reinforce the view that XSLJZD overcomes 5-fluorouracil (5-FU) resistance in GC by inducing PANoptosis."
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• "The mini-review by Mario Pescatori and colleagues offers a clinically relevant, experience-based overview of functional disorders associated with chronic constipation and obstructed defecation. The “iceberg model” presented by the authors is particularly valuable because it highlights the often-overlooked functional and psychological contributors to obstructed defecation. The article also effectively emphasizes the risks of inappropriate surgical intervention in patients with predominantly functional pathology and reinforces the importance of multidisciplinary management. The discussion of anxiety-depression, anismus, rectal hyposensitivity, and pudendal neuropathy is concise yet clinically meaningful. Including institutional experience alongside the literature review strengthens the article’s practical relevance. The proposed treatment strategies, particularly psycho-echo-biofeedback and selective puborectalis myotomy, provide useful insight into individualized management approaches. A few additional points could further strengthen the manuscript. Incorporating recent guideline-based recommendations from international colorectal and gastroenterology societies would reinforce the evidence-based framework of the review. A brief discussion of standardized diagnostic algorithms for pelvic floor dyssynergia, including the role of high-resolution anorectal manometry, may also improve completeness. In addition, a summary table outlining functional disorders, diagnostic modalities, and preferred management strategies would enhance readability for practicing clinicians and trainees. Overall, this article makes an important contribution to the understanding of functional constipation and obstructed defecation. It appropriately cautions against excessive reliance on surgery and underscores the need for careful functional evaluation before operative intervention. "
• "The article indicates that high PRMT5 expression is associated with poor prognosis in hepatocellular carcinoma (HCC). It further reveals that PRMT5 can suppress DDIT3 transcription by enhancing H4R3me2 modification at the DDIT3 promoter region and recruiting STAT3, thereby promoting anti-apoptotic behavior and malignant progression of tumor cells. This mechanism links epigenetic regulation, transcription factor cooperation, and tumor cell escape from apoptosis, providing a new perspective for understanding the development and progression of HCC. A key strength of the article is that it not only identifies the association between PRMT5 and prognosis, but also further elucidates the dual inhibitory mechanism by which PRMT5 regulates DDIT3, making the study’s conclusions more biologically convincing. "
• "This multicenter retrospective study provides valuable real-world evidence on the clinical presentation, endoscopic features, treatment patterns, and outcomes of eosinophilic gastroenteritis in the Busan and Gyeongnam regions of Korea. The study is clinically meaningful because eosinophilic gastroenteritis remains a relatively rare and heterogeneous disease, and regional data from Asian populations are still limited. A major strength of the article is its location-based analysis, which shows that gastroduodenitis, enterocolitis, and gastroenterocolitis may differ in symptoms, treatment selection, and relapse risk. The finding that patients with gastroduodenal involvement may respond well to proton pump inhibitor therapy is particularly interesting and may encourage clinicians to consider more individualized and less steroid-dependent strategies in selected patients. The observation that relapse was more frequent in enterocolitis also has practical relevance, as it highlights the need for closer follow-up in patients with colonic involvement. The manuscript is generally well organized, and the language is clear and accessible. From a critical perspective, the retrospective design, modest sample size, short median follow-up duration, and non-standardized treatment approaches across centers limit the ability to draw firm conclusions about predictors of treatment response or recurrence. The association between male sex and clinical response is intriguing but should be interpreted cautiously given the wide confidence interval. Future prospective multicenter studies with standardized diagnostic thresholds by gastrointestinal site, uniform treatment protocols, longer follow-up, and histological as well as symptomatic outcome measures would further strengthen the evidence base. Overall, this article makes a useful contribution to the understanding of eosinophilic gastroenteritis in Asian clinical practice and provides a solid foundation for future studies on tailored management strategies. "
• "This retrospective study displayed a critical role in the performing of training and testing results using several artificial techniques in the occurrence of acute kidney damage clinically. Although it is meaningful to indicate the incidence of acute kidney injury after clinical treatment, there are several issues to need further explanation for achieving better effect by readers such that the patient number difference between training and testing group presented significantly as well as the cross sections among acute kidney injury or non-acute kidney injury versus training cohort and validation cohort displayed without overlapped demonstration. "
• "Dearly respected Editor Greetings The authors touched an important topic in metabolic disease, metabolic-associated fatty liver disease (MAFLD) is common in particular in patients with type 2 diabetes mellitus which is approaching an epidemic. Nearly two-thirs of patients wirh diabetes are suffering from from MASLD with seroius consequences in terms of liver cirrhosis, hepatocellular carcinoma, and mortality. In addition, patients with MASLD have higher prevalence of type 2 diabetes. The current literatures shows significant geographic, age, and gender variation. Importantly, males had a higher rate of MASLD than women, but the mortality is higher in women. Although, the variation can be explained in part by the differences in hypertension, serum uric acid, and other cardiovascular risk factors. Genetic and sex hormone in particular sex-hormone binding globulins play important roles. Investigating the gender differences could direct personalized management specific for age and gender. This is an important hot topic in Medicine on which Iam very thrilled to write an editorial or an umbrella review. Best regards Hyder Mirghani, Peofessor of Internal Medicie, Endocrinology, and Metabolism, University of Tabuk, Saudi Arabia "
• "the current article addressed the role of vitamin D in pathogenesis and management of inflammatory bowel diseases. it is an interesting article as it paves the way for role of diets in management of IBD.in the same context, Functional medicine in Inflammatory Bowel Disease (IBD) aims to treat the root causes of inflammation rather than just managing symptoms, using personalized nutrition, lifestyle modifications, and gut-healing protocols "
• "Thank you for an interesting article. HAV is an important infection which cause acute hepatitis, including acute liver failure and acute-on-chronic liver failure. Liver transplantation is an option for patients with acute liver failure and patients with acute-on-chronic liver failure. This article provided an useful information for us. Thank you very much. "
• "This prospective observational study by Semeya et al. provides significant real-world evidence regarding the systemic implications of Helicobacter pylori (H. pylori) infection in high-risk patients on long-term low-dose aspirin. The authors elegantly demonstrate the clinical value of successful eradication in reducing both peptic ulcer bleeding (PUB) and cardiovascular disease (CVD) progression. This research is timely and offers practical guidance for the multidisciplinary management of these complex patients. However, a few methodological and technical nuances warrant further attention to enhance the study's scientific rigor. Most notably, a critical discrepancy exists in Table 4, where row labels such as "Endoscopic" and "Histopathological" appear under the "Cardiovascular disease" header instead of specific clinical conditions. Additionally, the P-value for ischemic heart disease is inconsistently reported as P < 0.001 in the text but P = 0.006 in Table 4. Furthermore, the overall eradication rate of 51.9% achieved with levofloxacin-based triple therapy and the relatively brief 6-month follow-up period for observing chronic CVD progression present opportunities for deeper discussion. The broad range of aspirin dosages (81–325 mg) utilized without stratified analysis may also act as a confounding factor. We are currently drafting a formal Letter to the Editor to provide a more detailed appraisal of these methodological considerations and to explore the integration of advanced diagnostic technologies for optimizing risk stratification in this vulnerable population. "
• "This retrospective study analyzed data from 5,986 patients in Zhejiang Province, China, to investigate the association between Helicobacter pylori (H. pylori) infection and colorectal cancer (CRC) and colorectal adenomas, particularly advanced adenomas (AAs). The prevalence of advanced adenomas was significantly higher in H. pylori–positive patients compared to uninfected individuals. Although the prevalence of CRC was also slightly higher in the infected group, the difference did not reach statistical significance. H. pylori infection was not associated with non-adenomatous polyps (NAPs) or low-risk adenomas (LRAs). Multivariate logistic regression analysis identified H. pylori infection as a risk factor for both advanced adenomas and CRC. No significant differences were observed in the prevalence of adenomas or CRC across degrees of H. pylori infection. In H. pylori–positive patients, CRC lesions were more frequently located in the distal colon (left colon and rectum). Male sex and older age were also identified as risk factors for advanced adenomas and CRC. This study suggests that H. pylori infection may contribute to the development of advanced adenomas and CRC and recommends prioritizing colonoscopic evaluation in H. pylori–positive patients. In particular, patients at high risk of advanced adenomas (H. pylori–positive, male, and elderly) may benefit from regular colonoscopic surveillance for early detection and treatment. It is a fascinating study. However, in my opinion, several concerns have been raised. In this study, H. pylori infection status and infection level were evaluated using gastric mucosal biopsy specimens, but the specific biopsy sites (e.g., antrum or corpus) were not described in detail. Generally, biopsy from the antrum and/or corpus is recommended for accurate detection of H. pylori, whereas this study refers only to “gastric mucosal specimens.” Furthermore, the manuscript does not address the distinction between viable and non-viable H. pylori, nor the clinical significance of non-viable bacteria. The assessment of H. pylori infection in this study appears to be based on the presence of organisms observed in histological specimens, which typically reflects viable bacteria associated with infection and disease risk. In contrast, non-viable bacteria do not confer infectivity but may still contribute to immune responses. In clinical practice, accurate diagnosis of H. pylori infection can be challenging, and this issue warrants further discussion. "
• "The meta-analysis by Mapouka et al., involving 10.7 million participants, provides critical evidence that lean MASLD patients share comparable risks for MASH, cardiovascular disease, and mortality with non-lean individuals. While non-lean patients show higher odds of fibrosis and steatosis, lean patients demonstrate lower risks of cirrhosis and hypertension. These findings reinforce that BMI alone is an insufficient standalone screening metric. Methodologically, however, extreme heterogeneity was observed for outcomes including fibrosis (94%), MASH (91%), and mortality (90.9%), suggesting substantial variance in study populations. Classification bias remains a concern due to inconsistent BMI thresholds ( "
• "Wuda granules in the inflammation-estrogen-microbiota axis Dina Johar* Department of Biochemistry and Nutrition, Faculty of Women for Arts, Sciences and Education, Heliopolis, Cairo, Egypt *Dina Johar, PhD. Department of Biochemistry and Nutrition Faculty of Women for Arts, Sciences, and Education Ain Shams University, Cairo, Egypt Phone:+2 01060782045 Email: [email protected] *To whom correspondence should be addressed Abstract The inflammation-estrogen-microbiota axis dynamically remodel one another in a two-way, body-wide control loop. In Chinses Traditional Medicine, Wuda granules (WDG), which are derived from simo decoction, have been used clinically, and modified to enhance intestinal motility, restore bowel activity, relieve obstruction-related discomfort, and promote stool and gas elimination. Given the high recurrence rates of post-surgical functional dyspepsia and related GI disorders such as paralytic ileus and mechanical intestinal obstruction, it remains a significant clinical challenge to determine whether targeted treatments with WDG alter gut bacteria to raise body estrogen levels. In this commentary, we highlight recent findings from Wang et al.(2026)[1]. We draw attention to the potential benefits of studying experimental models in parallel with multi-omics approaches. The commentary offers insights for clinical decision-making and pre-clinical trials. Keywords Wuda granules; Post-operative ileus; Proteomics; Gastroenterology; Probiotics; Isovaleric acid. Core Tip The study of Wang et al, (2026)[1], presents an interesting, rich, multi-omics evaluation of WDG in a mouse model of POI, suggesting involvement of estrogen signaling and gut microbiota. However, additional experimental controls and mechanistic evidence is necessary to be fully supported. In multi-omics approaches, addressing the statistical test descriptions, sample sizes for high-throughput assays, multiple testing corrections, and computational pipeline parameters is necessary to ensure the robustness of the conclusions. Further contextualization regarding the functional validation of the proposed estrogen-mediated mechanisms and the physiological interpretation of the metabolite data are insightful. Addressing these limitations will significantly strengthen the study's mechanistic conclusions. Background The WDG-based therapies have shown potential to treat intestinal motility, relieve obstruction-related discomfort and promote elimination of stools and gases. However, their success is limited by difficulty in ensuring survival and targeting in the harsh gastrointestinal environment, especially post-surgery. The paper by Wang et al., 2026[1], provides an interesting and rich multi-omics evaluation of WDG in a mouse model of Post-Operative Ileus (POI), suggesting involvement of estrogen signaling and gut microbiota activity. In the proteomics dataset, sham controls are used to distinguish biological changes caused by a specific disease or treatment from changes due to the experimental procedure itself, such as surgery or anesthesia[2]. Including sham analyses, helps research to identify proteins that are only dysregulated because of the condition being studied rather than the stress of the intervention, as this reduces bias and improves accuracy[3]. Although the experimental design by Wang et al.(2026)[1] included a sham group, the resultant proteomics analysis compared the WDG-treated and POI model groups to identify the differentially expressed proteins without indicating the inclusion of sham/healthy baseline controls in the clustering or Venn diagram analysis. Without a baseline comparator, their claim that "WDG substantially reverses POI-induced protein dysregulation." is not logically supported, since the data only show that WDG creates a different expression profile from the POI state. Including sham control in the proteomics data set to definitively determine whether WDG normalizes protein expression or induces a novel state is key to exclude causality claims. Further, the study relies heavily on high-dimensional data (proteomics, 16S rRNA sequencing and Short-Chain Fatty Acid (SCFA) profiling), yet there is no indication that multiple testing correction was applied. Evaluating thousands of proteins or microbial taxa using standard P values thresholds greatly increases the false-positive rate, while applying and reporting appropriate multiple testing corrections (i.e., False Discovery Rate/ Benjamini-Hochberg) for these analyses helps to clarify the method-derived conclusion. I.e., in the description of the proteomic Venn diagram, the study states that there are "348 proteins uniquely present in each group." It is highly improbable that the WDG-treated group and the POI model group contain exactly 348 unique proteins each. Estrogen receptors (ERs) are nuclear proteins that bind estrogens, acting as transcription factors. The two primary intracellular receptors, ERα and ERβ, often play distinct or opposing roles in cell proliferation[4], regulate the synthesis of specific RNAs and proteins, regulate complex metabolic processes, and influence inflammation. Beyond reproduction studies, controversial findings on ERβ expression levels in disease progression, prediction, prognosis, and therapy remain paradoxical. This may be partly due to the ERβ- compensatory expression associated with some antisera available for research[5]. The hormone effects on the brain are particularly interesting, as ERβ is involved in anxiety and aggression[6]. Various antiestrogen strategies have been used in research, such as the high-affinity ERβ antagonist PHTPP: (4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol), are ERβ-specific. PHTPP blocks ERβ signaling in vivo and in vitro, reducing the expression of target genes like the Minichromosome Maintenance Complex Component 5 (mcm5), which regulates cell growth. In the ERβ-KO mouse model, the gene coding for Erβ is permanently lost. Knocking down ERβ using ERβ-shRNA in ERβ-positive human bladder cancer BCa J82, 647v, and T24 Erβ-positive cell lines led to suppressed cell growth and invasion[7]. Further, pharmacological or genetic suppression of ERβ alter mitochondrial metabolism, resulting in metabolic dysregulation[8]. Systems‐based approaches have focused almost exclusively on the use of data‐driven approaches based on ever‐expanding ‘omics’ data sets, which had a profound impact on clinical immunology. However, they are neither determined nor restricted by previous biological knowledge. Specifically, the hypotheses and predictions generated by data‐driven models are generally abstract, and relate to patterns or correlations rather than to biological mechanisms. The Wang et al. study[1] states that the therapeutic effects of WDG are "mediated, at least in part, via ERβ-dependent signaling pathways." based on the restoration of ERβ levels. However, this observation is correlative. To establish a causal mechanistic link, performing in vivo experiment using an ERβ antagonist- as aforementioned- to determine whether blocking this receptor abrogates the anti-inflammatory and motility-restoring effects of WDG is an inevitable approach. Further, molecular docking data are used to suggest that WDG constituents (i.e. linderane and quercetin) "act as key ligands modulating estrogenic signaling.". While docking provides theoretical binding affinity, it cannot distinguish between receptor agonists and antagonists, nor does it prove functional modulation. Including in vitro functional assay (i.e. an ER transactivation/luciferase reporter assay) to confirm that these compounds actively stimulate ER signaling is informative. The conclusion proposes a unified "inflammation-estrogen-microbiota axis" as the key mechanism of WDG-mediated regulation of POI. The study investigates estrogen receptor expression, inflammatory markers, and microbial shifts simultaneously, without demonstrating a precise directional or causal relationship between these three compartments. Because it is fundamentally unclear whether ER activation induces microbial shifts, or if microbial metabolites induce ER activation and subsequent anti-inflammatory responses, emphasizing that WDG concurrently modulates these pathways is necessary, unless additional experiments (e.g., evaluating the microbiome in ER-antagonized mice) are performed to establish the sequence of the axis. Postoperative ileus is characterized by impaired or absent gastrointestinal motility. Isovaleric acid (IVA) is a BCFA produced in the gut as a microbial metabolite, specifically by fermentation of branched-chain amino acid (leucine) by the gut microbiota. The authors state that IVA promotes relaxation of colonic smooth-muscle cells and "thereby improves GI motility". The physiological context of this claim in the literature is unclear, as smooth muscle relaxation typically inhibits contractions and delays transit. Explicitly addressing how a mechanism of muscle relaxation resolves a hypomotility disorder, or if it instead plays a role in resolving localized spasms to allow for coordinated peristalsis is insightful. The authors appropriately acknowledged the lack of Fecal Microbiota Transplantation (FMT) as a limitation for verifying the role of the gut microbiota. To provide more actionable future directions, the authors should also propose experiments to isolate the direct versus indirect effects of WDG, such as treating POI mice with broad-spectrum antibiotics before WDG administration. This would help determine if the therapeutic efficacy of WDG is strictly dependent on microbial metabolites (i.e., IVA) or if direct pharmacological effects (i.e., direct ERβ agonism by absorbed WDG compounds) independently drive recovery. DECLARATIONS Funding This commentary did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The author declares that no honorarium, grant, or other form of payment was given to anyone to produce the manuscript. Conflict of interest The author declares no conflict of interest exists. Consent to publish Not applicable. Availability of data and materials All data generated or analyzed during this study are included in this published article. Acknowledgment N/A REFERENCES 1 Wang T, Xu Y, Ou Y, Xiong W, Luo L, Li J, et al. Wuda granules target estrogen receptors and modulate gut microbiota to alleviate postoperative ileus: A multi-omics perspective. World J Gastroenterol. 2026;32:115995. [DOI: 10.3748/wjg.v32.i15.115995] 2 Candamo-Lourido M, Dopico-López A, López-Arias E, López-Amoedo S, Correa-Paz C, Chantada-Vázquez MP, et al. Comparative brain proteomic analysis between sham and cerebral ischemia experimental groups. Int J Mol Sci. 2024. 25;14:7538. [doi.org/10.1101/2023.12.21.572908] PMID: 39062782; PMCID: PMC11277324. 3 Candamo-Lourido M, López-Arias E, López-Amoedo S, Correa-Paz C, Bravo S, Bugallo-Casal A, et al. Relevance of sham control group in preclinical animal studies of cereberal ischemia. 2023. [doi.org/10.1101/2023.12.21.572908]. 4 Eyster K. Methods Mol Biol. The Estrogen receptors: An overview from different perspectives. Methods Mol Biol. 2016;1366:1-10. [doi: 10.1007/978-1-4939-3127-9_1]. PMID: 26585122 5 Snyder MA, Smejkalova T, Forlano PM, Woolley CS. Multiple ERbeta antisera label in ERbeta knockout and null mouse tissues. J Neurosci Methods. 2010;188:226-34. [doi: 10.1016/j.jneumeth.2010.02.012]. PMID: 20170675; PMCID: PMC2854183. 6 Tomihara K, Soga T, Nomura M, Korach KS, Gustafsson JA, Pfaff DW, et al. Effect of ER-beta gene disruption on estrogenic regulation of anxiety in female mice. Physiol Behav. 2009;96:300-6. [doi: 10.1016/j.physbeh.2008.10.014.]. PMID: 18996135; PMCID: PMC2705464. 7 Hsu I, Chuang KL, Slavin S, Da J, Lim WX, Pang ST, et al. Suppression of ERbeta signaling via ERbeta knockout or antagonist protects against bladder cancer development. Carcinogenesis. 2014;35:651-61. [doi: 10.1093/carcin/bgt348]. 8 Manente AG, Valenti D, Pinton G, Jithesh PV, Daga A, Rossi L, et al. Estrogen receptor beta activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo. Oncogenesis. 2013;2:e72. [doi: 10.1038/oncsis.2013.32. PMID: 24061575; PMCID: PMC3816222]. "
• "The identification of the novel m.C15954T mutation in the mitochondrial tRNAThr/tRNAPro genes, as detailed in this study, represents a significant milestone in our understanding of the genetic landscape of Type 2 Diabetes Mellitus (T2DM). By employing a rigorous combination of pedigree analysis and cybrid cell modeling, the researchers have successfully linked a specific mitochondrial DNA mutation to a cascade of metabolic failures, including impaired ATP production, reduced membrane potential, and elevated oxidative stress. The positive significance of this work lies in its ability to pinpoint a precise molecular initiator for diabetes in a specific population, moving beyond general risk factors to a concrete, maternally inherited genetic driver. This discovery not only enriches the global database of mitochondrial pathogenic variants but also emphasizes the critical role of mitochondrial tRNA 3’-end processing in maintaining metabolic homeostasis. From the perspective of acupuncture and its potential for glycemic control (glucose lowering), this research offers profound mechanistic implications. While acupuncture is traditionally viewed through the lens of nervous system modulation, modern research increasingly suggests its capacity to influence cellular bioenergetics and mitochondrial health. The "potential value" of this study for the acupuncture field is twofold. First, it defines a specific "mitochondrial phenotype" of diabetes—characterized by high reactive oxygen species (ROS) and low oxidative phosphorylation—that could serve as a biological target for acupuncture intervention. Previous studies have indicated that electroacupuncture at specific acupoints like ST36 (Zusanli) or ST25 (Tianshu) can activate the SIRT1/PGC-1α signaling pathway, which is a master regulator of mitochondrial biogenesis and antioxidant defense. In patients carrying the m.C15954T mutation, acupuncture could potentially act as a "mitochondrial stabilizer," compensating for the genetic defect by enhancing the residual mitochondrial efficiency or promoting the clearance of dysfunctional mitochondria (mitophagy). Second, this research supports the development of "precision acupuncture." By identifying patients with specific mitochondrial mutations, clinicians could theoretically predict who might respond best to acupuncture treatments aimed at metabolic regulation. For instance, if the m.C15954T mutation leads to systemic bioenergetic deficits, acupuncture’s role in Improving microcirculation and oxygen delivery (as seen in your previous research on VEGF-A pathways) might be particularly beneficial in mitigating the downstream tissue damage caused by these mitochondrial failures. Ultimately, this paper provides a robust molecular foundation for future clinical trials investigating whether acupuncture can bypass or alleviate the metabolic bottlenecks created by mitochondrial tRNA mutations, thereby offering a non-pharmacological pathway to restore lipid and glucose balance in genetically predisposed individuals. "
• "the article raises new paradigm in understanding the mechanisms that lead to DR in all types of diabetic patients pointing to the false or invalid dependence of conventional glucose biomarkers rather than looking to the glycemic instabiliuty as the major contributing factor that leads to DR. the article did not discuss if this will have an impact on the prediabetic state or only glycemic instability effects apply to overt diabetic states. the article included details of limitations and future prospective that will enhance future research. "
• "Chronic radiation proctitis (CRP) is a common delayed complication following pelvic radiotherapy, among which refractory bleeding is one of the most challenging issues. Currently, effective oral drugs are lacking, and treatment mostly relies on endoscopic argon plasma coagulation (APC), enema preparations, or surgery, which are associated with high recurrence rates and significant invasiveness. Therefore, exploring safe and effective oral therapeutic agents holds important clinical value. This study focuses on thalidomide, an old drug with anti-inflammatory, immunomodulatory, and anti-angiogenic properties, for the treatment of refractory hemorrhagic CRP, filling a gap in clinical data on oral medications in this field. "
• "This cohort study has provided a review on the pediatric gastroenterology disease using genomic methods in Middle Eastern area. Hope that the flowchart to collect the proper cases in this study can be explained in view of author's efforts. In addition, the total candidate patients number may be added for solid foundation if possible. "
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• Elatrebi S, Abuyadek R, Abdelbar SMM, Ahmad MS, Ayyad M, Quoritem MA, Abdel Majid RO, Arafat M, Amgad A, Alnagar A. Redefining weight management after liver transplantation with glucagon-like peptide one and gastric inhibitory polypeptide receptor agonists.
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• Isa HM, Abdulaal FA, Busehail MY, Kamal MH, Alaswad HA, Alshaikh FY, Aljassmi AA, Hijris AJ. UGT1A1-related disorders in Bahrain: A genetic and clinical overview of Crigler-Najjar and Gilbert syndromes.
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• Lu Y, Zhou XL, Chen F. Letter to the Editor: Spinal IL-33/ST2 blockade for gallbladder carcinoma pain - balancing central analgesia with systemic tumor immune microenvironment risks.
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